Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases.

@article{Boehmer2006PosttranslationalRO,
  title={Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases.},
  author={Christoph Boehmer and M{\`o}nica Palmada and Jeyaganesh Rajamanickam and Roman Schniepp and Susan Gaye Amara and Florian Lang},
  journal={Journal of neurochemistry},
  year={2006},
  volume={97 4},
  pages={911-21}
}
The human excitatory amino acid transporter (EAAT)2 is the major glutamate carrier in the mammalian CNS. Defective expression of the transporter results in neuroexcitotoxicity that may contribute to neuronal disorders such as amyotrophic lateral sclerosis (ALS). The serum and glucocorticoid inducible kinase (SGK) 1 is expressed in the brain and is known to interact with the ubiquitin ligase Nedd4-2 to modulate membrane transporters and ion channels. The present study aimed to investigate… CONTINUE READING

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