Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.

Abstract

Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in Wnt signalling. In the present paper, the roles of the post-translational modifications in the actions of Wnt-5a were investigated. We found that Wnt-5a is modified with palmitate at Cys104 and glycans at Asn114, Asn120, Asn311 and Asn325. The palmitoylation was not… (More)

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@article{Kurayoshi2007PosttranslationalPA, title={Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.}, author={Manabu Kurayoshi and Hideki Yamamoto and Shunsuke Izumi and Akira Kikuchi}, journal={The Biochemical journal}, year={2007}, volume={402 3}, pages={515-23} }