Post-translational modifications required for coagulation factor secretion and function.

@article{Kaufman1998PosttranslationalMR,
  title={Post-translational modifications required for coagulation factor secretion and function.},
  author={Randal J Kaufman},
  journal={Thrombosis and haemostasis},
  year={1998},
  volume={79 6},
  pages={1068-79}
}
Protein translocation into and transport through the secretory pathway in eukaryotic cells is accompanied by a multitude of covalent modifications that occur on the polypeptide backbone. The sequence of post-translational modifications that occur on a polypeptide is carefully regulated both temporally and spatially, where certain modifications only occur within the endoplasmic reticulum (ER) and others only occur within the Golgi compartment (Fig. 1). In many cases these modifications are… CONTINUE READING