Post-translational modifications regulate the ticking of the circadian clock

  title={Post-translational modifications regulate the ticking of the circadian clock},
  author={Monica Gallego and David M. Virshup},
  journal={Nature Reviews Molecular Cell Biology},
Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them. 

The intricate dance of post-translational modifications in the rhythm of life

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A role for the proteasome in the light response of the timeless clock protein.

The sensitivity of TIM regulation by light was tested and suggested that TIM is degraded through a ubiquitin-proteasome mechanism, and TIM was ubiquitinated in response to light in cultured cells.