Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes

@inproceedings{Laedermann2015PosttranslationalMO,
  title={Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes},
  author={C{\'e}dric J. Laedermann and H. Abriel and Isabelle Decosterd},
  booktitle={Front. Pharmacol.},
  year={2015}
}
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke of the action potential (AP). Navs are composed of nine different isoforms with distinct biophysical properties. Studying the mutations associated with the increase or absence of pain sensitivity in humans, as well as other expression studies, have highlighted Nav1.7, Nav1.8, and Nav1.9 as… CONTINUE READING