Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

@article{Hori1991PosttranslationalMO,
  title={Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.},
  author={Yusuke S Hori and Akira Kikuchi and Minoru Isomura and Masanobu Katayama and Yoshiaki Miura and Hisashi Fujioka and Kozo Kaibuchi and Yoshimi Takai},
  journal={Oncogene},
  year={1991},
  volume={6 4},
  pages={515-22}
}
We have recently found, by use of the rhoA p21 purified from bovine aortic smooth muscle, that it is similarly post-translationally processed as described for ras p21s: it is first geranylgeranylated at the cysteine residue in the C-terminal region followed by removal of the three C-terminal amino acids and the subsequent carboxyl methylation of the… CONTINUE READING