Post-translational modifications of Runx1 regulate its activity in the cell.


In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

DOI: 10.1016/j.bcmd.2009.03.005

Cite this paper

@article{Wang2009PosttranslationalMO, title={Post-translational modifications of Runx1 regulate its activity in the cell.}, author={Lan Wang and Gang Huang and Xinyang Zhao and Megan A. Hatlen and Ly Vu and Fan Liu and Stephen D. Nimer}, journal={Blood cells, molecules & diseases}, year={2009}, volume={43 1}, pages={30-4} }