Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.

@article{Hermel1999PosttranslationalMO,
  title={Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.},
  author={J M Hermel and Ronald A Dirkx and Michele Solimena},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 8},
  pages={2609-20}
}
The autoantigen of type I diabetes ICA512 is a receptor tyrosine phosphatase-like protein enriched in the secretory granule membranes of neurons and peptide secreting endocrine cells. While the function of ICA512 remains unknown, it is thought to link regulated neuropeptide and peptide hormone secretion with signal transduction pathways involving tyrosine phosphorylation/dephosphorylation. To characterize further its biochemical properties, we conducted studies in the bovine pituitary, an… CONTINUE READING

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