Post-translational modification of transthyretin in plasma.

  title={Post-translational modification of transthyretin in plasma.},
  author={Hisayasu Terazaki and Yasuhiko Ando and Ole B. Suhr and P I Ohlsson and Konen Obayashi and Taro Yamashita and Shinichi Yoshimatsu and Moritaka Suga and Makoto Uchino and Masayuki Ando},
  journal={Biochemical and biophysical research communications},
  volume={249 1},
To determine the behavior of transthyretin (TTR) in blood circulation, TTR purified from normal subjects' plasma was injected to rats, and blood and urine were collected time dependently. Although TTR in plasma was proven to be a predominantly cysteine (Cys) conjugated form by electrospray ionization mass spectrometry (ESI-MS) analysis, it was gradually converted into free, 32 Da (dihydroxylation), 80 Da (phosphorylation), and 306 Da (glutathionylation), increased forms in molecular weight of… CONTINUE READING


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