Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.

@article{Raghuraman2010PosttranslationalMO,
  title={Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.},
  author={Gayatri Raghuraman and Nanduri R Prabhakar and Ganesh K. Kumar},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 6},
  pages={
          1568-78
        }
}
Intermittent hypoxia (IH) associated with sleep apnea leads to cardio-respiratory morbidities. Previous studies have shown that IH alters the synthesis of neurotransmitters including catecholamines and neuropeptides in brainstem regions associated with regulation of cardio-respiratory functions. GABA, a major inhibitory neurotransmitter in the CNS, has been implicated in cardio-respiratory control. GABA synthesis is primarily catalyzed by glutamic acid decarboxylase (GAD). In this study, we… CONTINUE READING