Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding.

@article{Prabakaran2012PosttranslationalMN,
  title={Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding.},
  author={Sudhakaran Prabakaran and Guy Lippens and Hanno Steen and Jeremy Gunawardena},
  journal={Wiley interdisciplinary reviews. Systems biology and medicine},
  year={2012},
  volume={4 6},
  pages={565-83}
}
We discuss protein post-translational modification (PTM) from an information processing perspective. PTM at multiple sites on a protein creates a combinatorial explosion in the number of potential 'mod-forms', or global patterns of modification. Distinct mod-forms can elicit distinct downstream responses, so that the overall response depends partly on the effectiveness of a particular mod-form to elicit a response and partly on the stoichiometry of that mod-form in the molecular population. We… CONTINUE READING
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