Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.

@article{Ito2007PosttranslationalMO,
  title={Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.},
  author={Ichiaki Ito and Jutarou Fukazawa and Michiteru Yoshida},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 22},
  pages={16336-44}
}
High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation. HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation. HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular… CONTINUE READING

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