Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.

@article{Trackman1992PosttranslationalGA,
  title={Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.},
  author={Philip C Trackman and D Bedell-Hogan and Jisen Tang and Herbert M. Kagan},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 12},
  pages={8666-71}
}
The synthesis and post-translational processing of a lysyl oxidase precursor protein predicted by the cDNA sequence of rat aorta lysyl oxidase were investigated. In vitro transcription of the cloned lysyl oxidase cDNA and cell-free translation of its mRNA transcript yielded a 47-kDa protein in the absence and a 50-kDa glycosylated protein in the presence of pancreatic membranes, each of which were immunoprecipitated with antibody against the 32-kDa bovine enzyme. Similarly, an N-glycosylated… CONTINUE READING

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