Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.

  title={Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-\{beta\}-induced collagen expression in kidney cells.},
  author={Mitsuo Kato and Lin Wang and Sumanth Putta and Mei Wang and Hang Yuan and Guangdong Sun and Linda L. Lanting and Ivan Todorov and John J. Rossi and Rama Natarajan},
  journal={The Journal of biological chemistry},
  volume={285 44},
Increased accumulation of extracellular matrix proteins and hypertrophy induced by transforming growth factor-β1 (TGF-β) in renal mesangial cells (MC) are hallmark features of diabetic nephropathy. Although the post-transcriptional regulation of key genes has been implicated in these events, details are not fully understood. Here we show that TGF-β increased microRNA-216a (miR-216a) levels in mouse MC, with parallel down-regulation of Ybx1, a miR-216a target and RNA-binding protein. TGF-β also… CONTINUE READING
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