Post-transcriptional regulation of vascular endothelial growth factor by hypoxia.

@article{Levy1996PosttranscriptionalRO,
  title={Post-transcriptional regulation of vascular endothelial growth factor by hypoxia.},
  author={Andrew P Levy and Nina S. Levy and Marc A. Goldberg},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 5},
  pages={
          2746-53
        }
}
The major control point for the hypoxic induction of the vascular endothelial growth factor (VEGF) gene is the regulation of the steady-state level of the mRNA. We previously demonstrated a discrepancy between the transcription rate and the steady-state mRNA level induced by hypoxia. This led us to examine the post-transcriptional regulation of VEGF expression. Actinomycin D experiments revealed that hypoxia increased VEGF mRNA half-life from 43 +/- 6 min to 106 +/- 9 min. Using an in vitro… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 275 CITATIONS, ESTIMATED 62% COVERAGE

The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.

  • Biochemical pharmacology
  • 2010
VIEW 2 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability.

  • Molecular biology of the cell
  • 1998
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Now a Nobel gas: oxygen

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1993
2019

CITATION STATISTICS

  • 9 Highly Influenced Citations