Post-transcriptional regulation of microRNA expression.

  title={Post-transcriptional regulation of microRNA expression.},
  author={Gregor Obernosterer and Philipp J.F. Leuschner and Mattias Alenius and Javier de La Puente Martinez},
  volume={12 7},
microRNAs (miRNAs) are endogenous, noncoding approximately 22-nucleotide RNA molecules that have recently emerged as fundamental, post-transcriptional regulators of cognate target gene expression. Many mammalian miRNAs are expressed in a tissue-specific manner, a phenomenon that has so far been attributed to transcriptional regulation. We here show by Northern blots and in situ hybridization experiments that the expression of mammalian miRNAs can be regulated at the post-transcriptional level… CONTINUE READING