Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript.

@article{Robb2004PosttranscriptionalRO,
  title={Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript.},
  author={Gregory B. Robb and Andrew R. Carson and Sharon C Tai and Jason E. Fish and Sundeep Singh and Takahiro Yamada and Stephen W. Scherer and Kazuhiko Nakabayashi and Philip A. Marsden},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 36},
  pages={37982-96}
}
Endothelial nitric-oxide synthase (eNOS) mRNA levels are abnormal in diseases of the cardiovascular system, but changes in gene expression cannot be accounted for by transcription alone. We found evidence for the existence of an antisense mRNA (sONE) that is derived from a transcription unit (NOS3AS) on the opposite DNA strand from which the human eNOS… CONTINUE READING