Post-transcriptional regulation of DNA damage-responsive gene expression.

Abstract

SIGNIFICANCE Production of proteins requires the synthesis, maturation, and export of mRNAs before their translation in the cytoplasm. Endogenous and exogenous sources of DNA damage pose a challenge to the co-ordinated regulation of gene expression, because the integrity of the DNA template can be compromised by DNA lesions. Cells recognize and respond to… (More)
DOI: 10.1089/ars.2013.5523

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