Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells.

@article{Deryusheva2012PosttranscriptionalMO,
  title={Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells.},
  author={Svetlana Deryusheva and Maria Choleza and Adrien Barbarossa and Joseph G Gall and R{\'e}my Bordonn{\'e}},
  journal={RNA},
  year={2012},
  volume={18 1},
  pages={31-6}
}
The survival of motor neuron (SMN) protein plays an important role in the biogenesis of spliceosomal snRNPs and is one factor required for the integrity of nuclear Cajal bodies (CBs). CBs are enriched in small CB-specific (sca) RNAs, which guide the formation of pseudouridylated and 2'-O-methylated residues in the snRNAs. Because SMN-deficient cells lack typical CBs, we asked whether the modification of internal residues of major and minor snRNAs is defective in these cells. We mapped modified… CONTINUE READING
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