Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

@article{Zhao2008PosttranscriptionalDO,
  title={Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.},
  author={Haotian Zhao and Olivier Ayrault and Fr{\'e}d{\'e}rique Zindy and Jee-Hae Kim and Martine F Roussel},
  journal={Genes & development},
  year={2008},
  volume={22 6},
  pages={722-7}
}
Bone morphogenic proteins 2 and 4 (BMP2 and BMP4) inhibit proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary GNP-like medulloblastoma (MB) cells. This occurs through rapid proteasome-mediated degradation of Math1 (Atoh1), a transcription factor expressed in proliferating GNPs. Ectopic expression of Atoh1, but not of Sonic hedgehog (Shh)-regulated Gli1 or Mycn, cancels these BMP-mediated effects and restores Shh-dependent proliferation of GNPs… CONTINUE READING

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