Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation.

@article{Weake2011PosttranscriptionIF,
  title={Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation.},
  author={Vikki M Weake and Jamie O Dyer and Christopher P Seidel and Andrew C. Box and Selene K Swanson and Allison Peak and Laurence Florens and Michael P Washburn and Susan M. Abmayr and Jerry L. Workman},
  journal={Genes & development},
  year={2011},
  volume={25 14},
  pages={1499-509}
}
The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex was discovered from Saccharomyces cerevisiae and has been well characterized as an important transcriptional coactivator that interacts both with sequence-specific transcription factors and the TATA-binding protein TBP. SAGA contains a histone acetyltransferase and a ubiquitin protease. In metazoans, SAGA is essential for development, yet little is known about the function of SAGA in differentiating tissue. We analyzed the composition… CONTINUE READING