Post-surgical assessment of excised tissue from patients with Buruli ulcer disease: progression of infection in macroscopically healthy tissue.

@article{Bretzel2005PostsurgicalAO,
  title={Post-surgical assessment of excised tissue from patients with Buruli ulcer disease: progression of infection in macroscopically healthy tissue.},
  author={Gisela Bretzel and Vera Siegmund and Paul Racz and Felicitas van Vloten and François Ngos and William Thompson and Paola Biason and Ohene Adjei and Bernhard Fleischer and Joerg Nitschke},
  journal={Tropical medicine & international health : TM & IH},
  year={2005},
  volume={10 11},
  pages={1199-206}
}
OBJECTIVE The current standard of treatment of Buruli ulcer disease (BUD) is surgical excision of lesions. Excision size is determined macroscopically assuming the complete removal of all infected tissue. However, dissemination of infection beyond the excision margins into apparently healthy tissue, possibly associated with recurrences, cannot be excluded in this way. To assess the central to peripheral progression of Mycobacterium ulcerans infection and the mycobacterial infiltration of… CONTINUE READING

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