Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats.

@article{Sandu2016PoststrokeGH,
  title={Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats.},
  author={Raluca Elena Sandu and Adriana Uzoni and Ovidiu Ciobanu and Mihai Moldovan and Andrei Anghel and Eugen Radu and A N Coogan and Aurel Popa-Wagner},
  journal={Restorative neurology and neuroscience},
  year={2016},
  volume={34 3},
  pages={401-14}
}
PURPOSE In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available. In animal studies of focal ischemia, short-term hypothermia often reduces infarct size. Nevertheless, efficient neuroprotection requires long-term, regulated lowering of whole body temperature. Previously, we reported that post-stroke exposure to hydrogen sulfide (H2S) effectively lowers whole body temperature and confers neuroprotection in aged animals. METHODS In the present… CONTINUE READING
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