Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells.

  title={Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells.},
  author={Liesbeth Peeters and Niek N Sanders and ARNOLDM. JONES and Joseph Demeester and Stefaan C. De Smedt},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={121 3},
The retinal pigment epithelium (RPE) is a potential tissue for gene therapy. We recently demonstrated that pegylation of lipoplexes prevents their aggregation in the vitreous of the eye. However, pegylation of lipoplexes may affect their gene transfer capacity. Therefore we studied the effect of pegylation of lipoplexes on the transfection of RPE cells. "Pre-pegylated" lipoplexes were prepared by mixing pDNA with pegylated liposomes, while "post-pegylated" lipoplexes were obtained by pegylation… CONTINUE READING

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