Post-orgasmic illness syndrome: history and current perspectives.

  title={Post-orgasmic illness syndrome: history and current perspectives.},
  author={Mark R Paulos and Gabriella J Avelliino},
  journal={Fertility and sterility},
  volume={113 1},
2 Citations
Novel treatment for post-orgasmic illness syndrome: a case report and literature review
A case of Post-orgasmic illness syndrome (POIS) that was successfully treated with surgery after failed immunosuppressive therapy is reported, and a standard treatment strategy using these therapies has not been established.


Postorgasm illness syndrome--a spectrum of illnesses.
It seems likely that postorgasm illness syndrome represents a spectrum of syndromes of differing etiologies, and treatment needs to be tailored to the likely cause.
Postorgasmic Illness Syndrome (POIS) in 45 Dutch caucasian males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1).
The combination of allergic and systemic flu-like reactions post-ejaculation together with a positive skin-prick test in the majority of males underscores the hypothesis of an "immunogenic" etiology of POIS, e.g., that POIS is caused by Type-1 and Type-IV allergy to the males' own semen, as soon it is triggered by ejaculation.
Benign coital headache relieved by partner’s pregnancies with implications for future treatment
  • S. Dexter
  • Medicine, Psychology
    BMJ Case Reports
  • 2010
The timing of the condition’s relief and return of symptoms suggested progesterone was an intrinsic factor in this, and the patient was able to prevent his attacks by taking oral norethisterone 5 mg.
Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2).
Two males with POIS were successfully treated by hyposensitization with autologous semen, which supports an immunogenic/allergic etiology and underscores the clinical implication for immunological sexual medicine.
Sexual dysfunction: Postorgasmic illness syndrome
New evidence supports the hypothesis that postorgasmic illness syndrome (POIS) in men involves a hyper-reactive immune response of the mucosal epithelium that lines the urinary tract to seminal fluid.
Postorgasmic illness syndrome (POIS) in a Chinese man: no proof for IgE-mediated allergy to semen.
The purpose of the current work was to characterize the first diagnosed POIS patient in China and to study the allergic response of autologous semen in the affected patient and in three healthy males and to identify the pattern of IgE reactivity to patient's semen.
Post orgasmic illness syndrome (POIS)
  • M. Waldinger
  • Biology, Medicine
    Translational andrology and urology
  • 2016
Post orgasmic illness syndrome is a chronic disorder that manifests itself in POIS “attacks” that occur within a few minutes to a few hours after ejaculation, and disappear spontaneously after 3 to 7 days.
Postorgasmic Illness Syndrome: Two Cases
The symptoms of a postejaculatory syndrome in two men with spontaneous ejaculations are described, which consists of severe fatigue, intense warmth, and a flulike state, with generalized myalgia.
A clinical case of suspected postorgasmic illness syndrome
  • J Sex Med
  • 2013