Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.

@article{Schou2005PostmortemHB,
  title={Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.},
  author={Magnus Schou and Christer Halldin and Victor W. Pike and P. David Mozley and David R Dobson and Robert B. Innis and Lars Farde and H{\aa}kan Hall},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2005},
  volume={15 5},
  pages={517-20}
}
The binding of the norepinephrine transporter radioligand, (S,S)-[18F]FMeNER-D2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus>>cortex approximately cerebellum approximately thalamus>caudate approximately putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram… CONTINUE READING

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PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2.

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