Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.

@article{Jayasekera2004PostmortemCO,
  title={Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.},
  author={Samantha Jayasekera and James Sissons and Julie Tucker and Claire Rogers and Debbie Nolder and David Charles Warhurst and Selwa Alsam and Jonathan M L White and Elisabeth M Higgins and Naveed Ahmed Khan},
  journal={Journal of medical microbiology},
  year={2004},
  volume={53 Pt 10},
  pages={1007-12}
}
The first isolation in the UK of Balamuthia mandrillaris amoebae from a fatal case of granulomatous amoebic meningoencephalitis is reported. Using primary cultures of human brain microvascular endothelial cells (HBMECs), amoebae were isolated from the brain and cerebrospinal fluid (CSF). The cultures showed a cytopathic effect at 20-28 days, but morphologically identifiable B. mandrillaris amoebae were seen in cleared plaques in subcultures at 45 days. The identification of the organism was… CONTINUE READING
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