Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

@article{Ikonomovic2008PostmortemCO,
  title={Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease},
  author={Milos D. Ikonomovic and William E. Klunk and Eric E. Abrahamson and Chester A. Mathis and Julie C. Price and Nicholas D. Tsopelas and Brian J. Lopresti and Scott K. Ziolko and Wenzhu Bi and William R. Paljug and Manik L. Debnath and Caroline E. Hope and Barbara A. Isanski and Ronald L. Hamilton and Steven DeKosky},
  journal={Brain},
  year={2008},
  volume={131},
  pages={1630 - 1645}
}
The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to beta-pleated sheet aggregates of the amyloid-beta (Abeta) peptide in vitro. The in vivo retention of PiB in brains of people with Alzheimer's disease shows a regional distribution that is very similar to distribution of Abeta deposits observed post-mortem. However, the basis for regional variations in PiB binding in vivo, and the extent to which it binds to different types of Abeta… CONTINUE READING

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X-34, a histofluorescent marker of abnormal protein aggregates with amyloid structure, in neuropathological studies of preclinical and clinical Alzheimer’s disease

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