Post-mastectomy Hypofractionation Radiotherapy in Breast Cancer Patients

  title={Post-mastectomy Hypofractionation Radiotherapy in Breast Cancer Patients},
  author={Elsayed Mostafa Ali and M Khalid Abd Almageed},
Background: Post-mastectomy radiotherapy reduces loco-regional recurrence in women with operable breast cancer and improves survival. Conventional fractionated radiotherapy has been limited by patient's compliance, travelling, unplanned interruption and others. Hypofractionated schedule would be more appealing and convenient. The present study was carried out to compare overall survival, disease free survival, loco regional control, and treatment toxicities, in patients treated with… 

Figures and Tables from this paper

Hypofractionated versus Conventionally Fractionated Radiotherapy in Post-Mastectomy Breast Cancer Patients
Post-mastectomy hypofractionated radiation therapy achieved comparable survival and toxicity to the conventionally fractionated radiotherapy with the advantage of reducing overall treatment time, treatment burden & cost.
Hypofractionated radiotherapy in post mastectomy locally advanced breast cancer: a study from a regional cancer center in North East India
In post mastectomy setting, HFRT is comparable to CFRT in terms of safety and efficacy, will be more convenient for patients and care givers and hence can be a routine standard practice.
Postmastectomy Hypofractionated Irradiation in Egyptian Patients with Breast Cancer: Zagazig University Experience
Hypofractionated radiotherapy was tolerated and has comparable outcome compared to conventional fractionation regarding local tumor control and treatment toxicities.
A Comparative Study of Hypofractionated and Conventional Radiotherapy in Postmastectomy Breast Cancer Patients
HF postmastectomy HF RT is comparable to conventional RT without evidence of higher adverse effects or inferior locoregional tumor control and has an added advantage of increased compliance because of short duration; hence, it can help in accommodating more breast cancer patients in a calendar year, ultimately resulting in decreased waiting list, increased turnover, and reduced cost of treatment.
A Study on Dosimetric Outcomes and Acute Toxicity of Post Mastectomy Adjuvant Hypofractionated Radiotherapy for Breast Cancer.
Adjuvant HFRT could be planned while meeting the dose constraints to normal tissues in all patients and was well tolerated, with mild to moderate acute adverse effects that did not warrant any therapeutic intervention or treatment interruption.
Study the Influence of Treatment Interruptions in the Radical Irradiation of Breast Cancer
Interruptions during postoperative hypofractionated irradiation of breast cancer (40 Gy/15 fractions/3weeks) should be avoided and if they are inevitable, they should not be prolonged more than two days, as they will adversely affect the treatment outcome (LRC).
Patterns of Practice in Radiotherapy for Breast Cancer in Korea
There were wide variations in the patterns of practice in breast RT in Korea, especially for regional nodal RT and omission of RT for ductal carcinoma in situ, and standard guidelines are needed.
Dosimetric study of hypo fractionated adjuvant post mastectomy radiotherapy with and without bolus and assessment of acute toxicity of treatment: a single institution study
Background: Moderate hypo fractionated PMRT is convenient for patients and is particularly beneficial in busy radiotherapy department like in developing nations. Furthermore, PMRT can be given with
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review
Compared to conventional fractionated radiotherapy, hypofractionate radiotherapy is not significantly different with respect to efficacy or toxicity in postmastectomy breast cancer.


Hypofractionation in post-mastectomy breast cancer patients: seven-year follow-up
Although acute skin reactions were higher in the hypofractionated arms, there was no significant difference in the local recurrence rates or late radiation effects, and a national randomized multicentre study is recommended.
A retrospective study comparing hypofractionated radiotherapy and conventional radiotherapy in postmastectomy breast cancer.
HFRT is as effective as CRT in postmastectomy breast cancer and no difference of toxicities including changes in chest wall appearance, skin fibrosis, brachial plexopathy, arm edema, pulmonary fibrosis and rib fractures and cardiovascular events was found between two groups.
Hypofractionated radiotherapy after conservative surgery for breast cancer: analysis of acute and late toxicity
The hypofractionated schedule delivering 45 Gy in 20 fractions shortened the overall treatment time by 1 week with a reduction of skin acute toxicity and no increase of late effects compared to the conventional fractionation.
Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer.
Radiotherapy combined with chemotherapy after modified radical mastectomy decreases rates of locoregional and systemic relapse and reduces mortality from breast cancer.
Hypofractionated radiotherapy in the treatment of early breast cancer.
It is therefore advisable that both possible dose inhomogeneity and normal tissue protection should be taken into account and the appropriate technology such as three-dimensional/intensity modulated radiation therapy employed in clinical practice, when hypofractionation is used.
Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer: early skin reactions and cosmetic results.
Preliminary results support the use of a shorter fractionation schedule of 42.5Gy/16f/22 days in patients with breast conserving surgery, and Lumpectomy volume and lumpectomy/breast volume ratio were the only factors that significantly affected the cosmetic appearance.
Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer.
The more convenient 22-day fractionation schedule appears to be an acceptable alternative to the 35-day schedule in reducing recurrence of invasive breast cancer.
Clinical experience using hypofractionated radiation schedules in breast cancer.