Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.

@article{Simpson2009PostID,
  title={Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.},
  author={John Alastair Simpson and Frank Sundler and D J Humes and David Jenkins and John Howard Scholefield and Robin C Spiller},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2009},
  volume={21 8},
  pages={847-e58}
}
Some patients with colonic diverticula suffer recurrent abdominal pain and exhibit visceral hypersensitivity, though the mechanism is unclear. Prior diverticulitis increases the risk of being symptomatic while experimental colitis in animals increases expression of neuropeptides within the enteric nervous system (ENS) which may mediate visceral hypersensitivity. Our aim was to determine the expression of neuropeptides within the ENS in diverticulitis (study 1) and in patients with symptomatic… CONTINUE READING

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