Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link

@article{Ghoshal2017PostinfectiousIT,
  title={Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link},
  author={Uday Chand Ghoshal and Kok Ann Gwee},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2017},
  volume={14},
  pages={435-441}
}
  • U. Ghoshal, K. Gwee
  • Published 17 May 2017
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
Evidence is emerging that IBS, a hitherto enigmatic disorder thought to be predominantly related to psychological factors, has a microorganic basis in a subset of patients with the disease. Post-infectious IBS (PI-IBS), commonly of the diarrhoea-predominant subtype (defined as new development of IBS following acute infectious diarrhoea), is one such condition known to occur in up to 10–30% individuals after acute gastroenteritis. However, following acute infectious gastroenteritis, patients can… 

Postinfection Irritable Bowel Syndrome

TLDR
Patients with PI-IBS present with either diarrhea-predominant IBS or the mixed subtype of IBS, and overlap with other FGIDs, such as functional dyspepsia is common, and the drugs used to treat non-constipation IBS may also be useful in PI- IBS treatment.

Post-Infectious Irritable Bowel Syndrome

TLDR
PI-IBS has many overlapping features with IBS-D and shares similar pathophysiology and management approaches and in some difficult cases, a combination of drugs that target the Pathophysiology may be helpful.

Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition

TLDR
Frequency of PI-IBS was similar among patients with cholera and those with other infection causing acute gastroenteritis, further proving the role of V. cholerae in the development of this condition.

Long‐Term Gastrointestinal Consequences are Frequent Following Sporadic Acute Infectious Diarrhea in a tropical country: A Prospective cohort Study

TLDR
FGIDs are common after acute gastroenteritis; dyspeptic symptoms, CBD, and weight loss were risk factors for PIFGIDs.

Small Intestinal Bacterial Overgrowth In Various Functional Gastrointestinal Disorders: A Case–Control Study

TLDR
Amongst various FGIDs, only IBS-D is significantly associated with SIBO, and no difference was found in the prevalence of methane-positive SIBO between chronic constipation (constipation-predominant IBS and FC) compared to controls.

Unique strain of Bifidobacterium longum and its efficacy in irritable bowel syndrome

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders affecting between 5 and 15% of the general adult population worldwide. Over the course of many years altered

раздраженного Unique strain of Bifidobacterium longum and its efficacy in irritable bowel syndrome

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders affecting between 5 and 15% of the gen-eral adult population worldwide. Over the course of many years altered

Post-infection Irritable Bowel Syndrome.

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.

TLDR
An algorithm for diagnosis and treatment of PI-IBS is presented, based on clinical presentation and potential disease mechanisms, and a consensus-based treatment algorithm is presented based on team consensus is presented.

The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO)

  • E. Quigley
  • Medicine
    Current Gastroenterology Reports
  • 2019
TLDR
SIBO, once removed from its original confines as a cause of malabsorption syndrome, has proven to be an elusive and moving target and only the most rigorous studies employing validated methodologies will finally corral this mysterious entity.

References

SHOWING 1-10 OF 117 REFERENCES

Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome. Evidence from a multicentre study in Romania.

TLDR
This study is the first to estimate the prevalence of SIBO in ibs patients from Romania and finds that rifaximin is effective in treating SI BO in IBS patients and controlled trials are warranted.

Frequency of Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome and Chronic Non-Specific Diarrhea

TLDR
SIBO was more common in CNSD including D-IBS than other types of IBS and HC, and was commoner in CNSd than HC.

Small Intestinal Bacterial Overgrowth and Lactose Intolerance Contribute to Irritable Bowel Syndrome Symptomatology in Pakistan

TLDR
SIBO was seen in a significant number of patients with IBS-D, and there was no significant age or gender difference in patients with or without SIBO.

Small intestine bacterial overgrowth in patients with irritable bowel syndrome.

TLDR
The results indicate that SIBO is relatively frequent in IBS patients and that execution of a lactulose BT should be encouraged in all these patients, being the only way to make correct diagnosis of SIBO and establish a valid therapeutic treatment.

Irritable bowel syndrome and small intestinal bacterial overgrowth: meaningful association or unnecessary hype.

TLDR
This review evaluates studies on association between SIBO and IBS, discordance between different studies, their strength and weakness including methodological issues and evidence on therapeutic manipulation of gut flora on symptoms of IBS.

[The development of irritable bowel syndrome after Shigella infection: 3 year follow-up study].

TLDR
The clinical course and prognosis of PI-IBS three years after shigella infection is investigated and it is concluded that bacterial gastroenteritis is a trigger factor of IBS.

Bugs and irritable bowel syndrome: The good, the bad and the ugly

TLDR
It appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms ofIBS.

Small intestine bacterial overgrowth in irritable bowel syndrome: a retrospective study with rifaximin.

TLDR
Data indicate a SIBO syndrome is present in about half of patients with an IBS diagnosis and, therefore, it should always be suspected in these patients and the use of broad-spectrum non absorbable antibiotics, such as rifaximin, represents a safe and effective approach to SIBO with a low risk of causing microbial resistance.

Factors associated with the development of post-infectious functional gastrointestinal diseases: does smoking play a role?

TLDR
Smoking was significantly associated with the development of a post-infectious FGID and appears to be associated with smoking, adding to increasing evidence for an organic basis to post- infected FGIDs, perhaps moderated via inflammatory pathways.

Small intestinal bacterial overgrowth in patients with irritable bowel syndrome

TLDR
The data do not support an important role for SIBO according to commonly used clinical definitions, in irritable bowel syndrome, however, mildly increased counts of small-bowel bacteria seem to be more common in IBS, and needs further investigation.
...