Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates

@article{Plautz2003PostinfarctCP,
  title={Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates},
  author={Erik J. Plautz and Scott Barbay and Shawn B. Frost and Kathleen Friel and Numa Dancause and Elena V. Zoubina and Ann M. Stowe and Barbara M. Quaney and Randolph J. Nudo},
  journal={Neurological Research},
  year={2003},
  volume={25},
  pages={801 - 810}
}
Abstract Stroke is often characterized by incomplete recovery and chronic motor impairments. A nonhuman primate model of cortical ischemia was used to evaluate the feasibility of using device-assisted cortical stimulation combined with rehabilitative training to enhance behavioral recovery and cortical plasticity. Following preinfarct training on a unimanual motor task, maps of movement representations in primary motor cortex were derived. Then, an ischemic infarct was produced which destroyed… Expand
Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions
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Results suggest that CS-induced functional improvements may be mediated by synaptic structural plasticity in stimulated cortex, and provide further support that CS can promote functional recovery. Expand
Enhanced Motor Recovery After Stroke With Combined Cortical Stimulation and Rehabilitative Training Is Dependent on Infarct Location
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The efficacy of CS for enhancing motor recovery after stroke may depend in part on the extent and location of the ischemic infarct. Expand
Cortical Stimulation Concurrent With Skilled Motor Training Improves Forelimb Function and Enhances Motor Cortical Reorganization Following Controlled Cortical Impact
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The data suggest that CS may be useful for improving rehabilitation efficacy after TBI but also raise the possibility that the CS parameters that are highly effective following stroke are suboptimal after moderate/severe TBI. Expand
Distributed Versus Focal Cortical Stimulation to Enhance Motor Function and Motor Map Plasticity in a Rodent Model of Ischemia
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The results indicate that although both focal and distributed forms ofCS/RT promote motor map reorganization only the distributed form of CS/RT enhances motor performance with rehabilitation. Expand
Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
TLDR
The results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke. Expand
Effects of Subdural Monopolar Cortical Stimulation Paired With Rehabilitative Training on Behavioral and Neurophysiological Recovery After Cortical Ischemic Stroke in Adult Squirrel Monkeys
TLDR
Results suggest that the specific parameters utilized here were not optimal for promoting behavioral recovery in nonhuman primates, and the present finding has cautionary implications for translation of CS/RT therapy to clinical populations. Expand
Cortical electrical stimulation combined with rehabilitative training: Enhanced functional recovery and dendritic plasticity following focal cortical ischemia in rats
TLDR
The efficacy of combining rehabilitative training with cortical electrical stimulation to improve functional outcome and cortical neuronal structural plasticity following sensorimotor cortical damage is supported. Expand
Enduring Poststroke Motor Functional Improvements by a Well–Timed Combination of Motor Rehabilitative Training and Cortical Stimulation in Rats
TLDR
CS can enhance the persistence, as well as the magnitude of RT-driven functional improvements, but its effectiveness in doing so may vary with time postinfarct. Expand
Cortical stimulation improves skilled forelimb use following a focal ischemic infarct in the rat
TLDR
Cortical stimulation, concurrent with rehabilitative training, results in better forelimb usage that may be due to augmented synaptic plasticity, and this was initially due to a shift in Forelimb preference. Expand
Neural Plasticity And Functional Recovery Following Cortical Ischemic Injury
  • E. Plautz, R. Nudo
  • Psychology, Medicine
  • 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
  • 2005
TLDR
It is concluded that electrical stimulation combined with rehabilitation enhanced plastic reorganization of the affected motor cortex, leading to superior behavioral recovery. Expand
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