Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?

@article{Meloni2007PostgenomicEA,
  title={Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?},
  author={Rolando Meloni and Nicole Faucon Biguet and Jacques Mallet},
  journal={Molecular Neurobiology},
  year={2007},
  volume={26},
  pages={389-403}
}
The microsatellite HUMTH01, located in the first intron of the Tyrosine Hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines), is characterized by a TCAT repeated motif and has been used in genetic studies of neuropsychiatric and other complex diseases, in which catecholaminergic neurotransmission is implicated. After reporting a positive association between HUMTH01 and bipolar disorder as well as schizophrenia, the authors established that HUMTH01 alleles… 
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TLDR
It is shown that allelic variations of HUMTH01 commonly found in humans have a quantitative silencing effect on TH gene expression, and this repeated sequence may contribute to the control of expression of quantitative genetic traits.
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TLDR
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TLDR
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TLDR
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