Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?

  title={Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?},
  author={Rolando Meloni and Nicole Faucon Biguet and Jacques Mallet},
  journal={Molecular Neurobiology},
The microsatellite HUMTH01, located in the first intron of the Tyrosine Hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines), is characterized by a TCAT repeated motif and has been used in genetic studies of neuropsychiatric and other complex diseases, in which catecholaminergic neurotransmission is implicated. After reporting a positive association between HUMTH01 and bipolar disorder as well as schizophrenia, the authors established that HUMTH01 alleles… 
[Association of the tyrosine hydroxylase gene polymorphism with schizophrenia in the population of central Poland].
Differences in the susceptibility to schizophrenia depending on polymorphic allele variants in repetitive TCAT sequence in TH01 locus may be associated with the function of a regulatory element in the process of TH gene transcription.
Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia
A meta-analysis of association between the three genes and schizophrenia, which may implicate the involvement of TPH in the pathogenesis of schizophrenia, has potentially important clinical, scientific and public health implications as well as providing a putative basis for the study of hydroxylase-related drugs.
Role of the Y chromosome in sex differences in ADHD and schizophrenia
Y chromosome variation does not appear to be associated with ADHD or schizophrenia, but there was evidence of a possible modifying effect on the phenotype of ADHD and schizophrenia and it may modify cognitive performance and clinical features.
Transgenic mice expressing yellow fluorescent protein under control of the human tyrosine hydroxylase promoter
Results indicate that the 3.2‐ kb sequence upstream of the TH gene is not sufficient for proper expression and that the 2‐kb sequence from the translation start site to exon 3 is necessary for expression of EYFP in a subset of catecholaminergic neurons.
Use of Natural Compounds from Plant Sources as AchE Inhibitors for the Treatment of Early Stage Alzheimer ’ s disease-An Insilico Approach
The results reveal that naturally occurring nonprotein compounds polygala and Jatrorrhizine are freely available natural compounds that can be safely used to prevent Alzheimer’s Disease and use less energy to bind to acetylcholinesterase enzyme and inhibit its activity.
Sex and Age Specificity of Susceptibility Genes Modulating Survival at Old Age
It is found that genetic variability plays a stronger role in males than in females and that, in both genders, its impact is especially important at very old ages.
Personality Genetics and Health in Super-Seniors


Quantitative effects on gene silencing by allelic variation at a tetranucleotide microsatellite.
It is shown that allelic variations of HUMTH01 commonly found in humans have a quantitative silencing effect on TH gene expression, and this repeated sequence may contribute to the control of expression of quantitative genetic traits.
No association between the tyrosine hydroxylase microsatellite marker HUMTH01 and schizophrenia or bipolar I disorder
Analysis of the segregation of the Ep allele in the family of one of the schizophrenic patients showed no transmission of this allele from the healthy mother to her schizophrenic daughter, and a non-significant trend towards an association between HUMTH01 allele D ([TCAT]9) and schizophrenia was observed.
Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia
The results suggest that the polymorphic intron 1 of the human TH gene may be associated with disturbances of the catecholamine pathway in schizophrenia.
An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample
It is suggested that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.
Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study.
The results of this association study do not confirm the possible implication of TH polymorphism in the susceptibility to BPAD and genetic and phenotypic heterogeneity may partially explain the difficulty of confirming the exact role of this gene using both association and linkage methods.
The TiPS/TINS lecture. Catecholamines: from gene regulation to neuropsychiatric disorders.
  • J. Mallet
  • Biology
    Trends in pharmacological sciences
  • 1996
Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia
During treatment with antipsychotic drugs patients with the rare allele displayed lower plasma homovanillic acid and 3-methoxy-4-hydroxyphenylglycol levels than those without.