Post-finasteride syndrome

  title={Post-finasteride syndrome},
  author={S. Lauren Gray and Todd P. Semla},
Efforts to explain persistent symptoms are undermined by poor long term data on harms 
Post-finasteride syndrome: a surmountable challenge for clinicians.
  • A. Traish
  • Medicine, Psychology
    Fertility and sterility
  • 2020
Post-finasteride syndrome: An emerging clinical problem
Post-finasteride syndrome: our current knowledge
The results of studies on sexual, physical, and psychological disorders have shown mixed results and some experts attribute post-finasteride syndrome to a group of «mysterious diseases» based on psychosocial factors.
The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli
The results suggest that FIN impairs stress reactivity and reduces behavioral activation and impulsive behavior by altering the function of the hypothalamus–pituitary–adrenal (HPA) axis.
Adverse drug reactions
In this clinical update, some principles that guide prevention, recognition, and response to adverse drug reactions are described.
Post-Finasteride Syndrome - When will we Get the Courage to Fight the Dictating Pharma Industry - Despite Awareness of "Sexual, Neurological and Metabolic Side Effects in Young Men for Over a Decade"
This comprehensive review has been done with an effort for the medical community who took hippocratic oath to serve the humanity why they cannot get up and protest against the side effects that in a subgroup of men might get irreversible side effects rather than label the poor men as psychotic or delusional.
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
Treating androgenetic alopecia therapy remains challenging as treatment selection involves ethical, evidence-based decision-making and consideration of each individual patient's needs, compliance, budget, extent of hair loss, and aesthetic goals, independent of potential financial benefits to the practitioners.
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism
This new guideline has been compiled using expertise from endocrine (medical and nursing), primary care, clinical biochemistry, urology and reproductive medicine practices to provide all care providers with a multidisciplinary approach to treating patients with male hypogonadism.
Sexual Dysfunctions Related to Drugs Used in the Management of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Narrative Review on α-Blockers and 5-Alpha Reductase Inhibitors
A critical review of the current literature data about sexual dysfunction as a potential side effect related to drugs commonly used for the treatment of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms finds that silodosin appears to have the highest incidence of ejaculatory disorders.


Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome
The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and mood changes during treatment with 5-alpha-reductase inhibitors including finasteride and dutasteride.
Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low‐Dose Finasteride: A Pharmacovigilance Study
The aim of this study was to detect signals of persistent sexual dysfunction and suicidal ideation secondary to low‐dose finasteride use in young men.
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases
Clinical reports of post-SSRI sexual dysfunction, post-finasteride syndrome and enduring sexual dysfunction following isotretinoin point to a legacy syndrome or syndromes comprising a range of disturbances to sexual function.
Post-finasteride syndrome – does it really exist?
The prolonged use of 5α-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background.
Finasteride and androgenic alopecia; from therapeutic options to medical implications
Several factors presented in this paper appear to explain finasteride inconsistency regarding its therapeutic and side effects, and should be further investigated and used to categorize subjects into distinct subgroups, either predisposed to adverse reactions or more tolerant of the finasterid administration.
Emotional Consequences of Finasteride: Fool’s Gold
Results provide evidence on the need to screen for psychiatric history and counseling patients about the potential psychological consequences of finasteride, and prescribing clinicians should carefully weigh the risk/benefit ratio with these patients.
Finasteride-associated male infertility.
It is hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasterid could occur.
Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride
To assess whether longer duration of 5α-RI exposure increases risk of PED, independent of age and other known risk factors, a single-group study design and classification tree analysis (CTA) was used to model PED.
Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients
Persistent sexual side effects of finasteride: could they be permanent?
  • M. Irwig
  • Psychology, Medicine
    The journal of sexual medicine
  • 2012
In most men who developed persistent sexual side effects despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years, which should be made aware of the potential adverse medication effects.