Post-exposure therapy in mice against experimental rabies: a single injection of DNA vaccine is as effective as five injections of cell culture-derived vaccine.

@article{Bahloul2003PostexposureTI,
  title={Post-exposure therapy in mice against experimental rabies: a single injection of DNA vaccine is as effective as five injections of cell culture-derived vaccine.},
  author={Chokri Bahloul and Sami Ben Hadj Ahmed and Beya Imen B'chir and Habib Kharmachi and El Akrem Hayouni and Koussay Dellagi},
  journal={Vaccine},
  year={2003},
  volume={22 2},
  pages={177-84}
}
Two rabies post-exposure therapies were comparatively evaluated: BALB/c mice were challenged at day 0 with rabies virus and then received either a single dose of rabies DNA vaccine administered at day 0, or five doses of cell culture-derived rabies vaccine administered at days 0, 3, 7, 15 and 28. Both regimens, rapidly triggered protective levels of neutralizing antibodies against rabies virus in vaccinated mice. In addition, one injection of DNA vaccine protected 53% of the challenged mice… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS