Post-exposure Treatment with Anti-rabies VHH and Vaccine Significantly Improves Protection of Mice from Lethal Rabies Infection

@inproceedings{Terryn2016PostexposureTW,
  title={Post-exposure Treatment with Anti-rabies VHH and Vaccine Significantly Improves Protection of Mice from Lethal Rabies Infection},
  author={Sanne Terryn and Aur{\'e}lie Francart and Heidi Rommelaere and Catelijne Stortelers and Steven Van Gucht},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
Post-exposure prophylaxis (PEP) against rabies infection consists of a combination of passive immunisation with plasma-derived human or equine immune globulins and active immunisation with vaccine delivered shortly after exposure. Since anti-rabies immune globulins are expensive and scarce, there is a need for cheaper alternatives that can be produced more consistently. Previously, we generated potent virus-neutralising VHH, also called Nanobodies, against the rabies glycoprotein that are… CONTINUE READING
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