Post-exercise nasal vasoconstriction and hyporeactivity: possible involvement of neuropeptide Y.

  title={Post-exercise nasal vasoconstriction and hyporeactivity: possible involvement of neuropeptide Y.},
  author={J. Sylvain Lacroix and Fernando Correia and Marwa S. Fathi and Eric Grouzmann},
  journal={Acta oto-laryngologica},
  volume={117 4},
Neuropeptide Y (NPY) is co-localized with noradrenaline (NA) in perivascular sympathetic nerve and is a vasoconstrictor. Pre-treatment with exogenous NPY markedly reduced nasal airway obstruction and rhinorrhea induced by the irritant capsaicin in control subjects. The aim of the present experiments was to study the time course variations of plasma concentrations of NA and NPY during and after intense exercise in 17 healthy volunteers. In parallel, changes in nasal airway resistance (NAR) were… 

Efeito do exercício físico sobre o volume nasal

Aerobic exercises, generally, increases the nasal volume, however, the increase of nasal volume was transitory, and occurs a major reduction of increase in the first ten minutes after the exercises ends, and perform a greater vasoconstrictor effect over nasal mucosa.

Nasal functional modifications after physical exercise: olfactory threshold and peak nasal inspiratory flow.

The active vasoconstriction of nasal mucosa associated with the reduction of blood flow to the olfactory epithelium due to physical exercise may be compensated for by the increase of Olfactory molecules that reach the ofactory mucosa because of nose mucosal shrinkage: this mechanism could explain the stability of mean olfFactory threshold after physical exercise.

Acoustic rhinometric evaluation of the nasal response to exercise in patients with nasal septal deviation.

The results of this study indicated that, in nasal septal deviation, the mucosal response is more prominent in the concave nasal cavities than in the convex nasal Cavities.

Evaluation of Nasal Volume by Acoustic Rhinometry before and after Physical Exercise

Physical exercise in general causes a significant increase in nasal volume, with the duration of exercise exerting a greater effect on the degree of improvement than intensity.

Can Sex Improve Nasal Function?-An Exploration of the Link Between Sex and Nasal Function.

Sexual intercourse with climax can improve nasal breathing to the same degree as application of nasal decongestant for up to 60 minutes in patients having nasal obstruction.

Investigation of the role of exercise and restrained eating behaviour on appetite control

Evidence is provided for a positive role of exercise on appetite regulation and weight maintenance, reinforcing the need to meet current national physical activity targets and the role of dietary restraint in predicting disinhibition.

NPY in allergic and respiratory disorders

There is an abundant literature available regarding the involvement of NPY in airway homeostasis. However, there is no NPY-related therapeutic agent yet available or under clinical development for



Adrenergic and non-adrenergic mechanisms in sympathetic vascular control of the nasal mucosa.

  • J. Lacroix
  • Biology, Medicine
    Acta physiologica Scandinavica. Supplementum
  • 1989
The data suggest that NA and NPY release in the pig nasal mucosa is regulated by prejunctional alpha-adrenoceptor mechanisms.

Modulation by neuropeptide Y of parasympathetic nerve‐evoked nasal vasodilatation via Y2 prejunctional receptor

It is concluded that sympathetic nerve stimulation attenuates parasympathetic vasodilatation via NPY release acting on prejunctional Y2 receptors.

Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects

Intranasal application of exogenous NPY has very low systemic absorption but induced long lasting nasal vasoconstriction without cardiovascular effects, and subjective nasal obstruction, local discomfort, nasal secretions and NAR increase evoked by capsaicin were markedly reduced by NPY pretreatment.

Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission

A complex interplay seems to occur at both the pre‐ and postjunctional levels of transmission for the classical transmitter NA and the coexisting peptide NPY, creating a great diversity of chemical signalling potential.

Capsaicin and nicotine‐sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis

The nasal secretory response, in man, to both capsaicin and nicotine, seems to be mediated via cholinergic parasympathetic reflexes, and challenge with irritant agents seems a useful test for the evaluation of both afferent and efferent reflexogenic responses in hyperreactive disorders of the nasal mucosa.

Exercise and nasal patency.

Nasal airflow resistances were studied in 20 healthy subjects at rest, with exercise, and during recovery from exercise; an initial sudden decrease was followed by a more gradual but progressive decrease, which continued for several minutes following vigorous short duration exercise.

Effect of neuropeptide Y on vasodilation mediated by calcitonin gene-related peptide (CGRP)-containing nerves in the mesenteric resistance vessel of the rat.

Results suggest that NPY modulates the release of CGRP from C GRP-containing nerves in mesenteric resistance vessels.

Nasal airway response to exercise.