Post-entry restriction of retroviral infections.

  title={Post-entry restriction of retroviral infections.},
  author={Greg J. Towers and Stephen P Goff},
  journal={AIDS reviews},
  volume={5 3},
Pathogenic retroviruses have driven the evolution of several dominant-acting mechanisms able to block infection and protect the host. These are exemplified by the mouse gene Fv1, which encodes a Gag-like protein able to protect against murine leukemia virus (MLV) infection. The block is saturable, occurs after reverse transcription and is directed against the viral capsid gene. Several other mammalian species are also able to block MLV infection with the same capsid specificity. A human gene… CONTINUE READING


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