Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.

  title={Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.},
  author={Gavin A Bewick and James Gardiner and Waljit S. Dhillo and Aysha S Kent and Nicholas E. White and Zoe Webster and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={19 12},
Agouti-related protein (AgRP) and neuropeptide Y (NPY) are colocalized in arcuate nucleus (arcuate) neurons implicated in the regulation of energy balance. Both AgRP and NPY stimulate food intake when administered into the third ventricle and are up-regulated in states of negative energy balance. However, mice with targeted deletion of either NPY or AgRP or both do not have major alterations in energy homeostasis. Using bacterial artificial chromosome (BAC) transgenesis we have targeted… CONTINUE READING


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