Post-cyclosporine-mediated hypertension and nephropathy: amelioration by vascular endothelial growth factor.

  title={Post-cyclosporine-mediated hypertension and nephropathy: amelioration by vascular endothelial growth factor.},
  author={Duk Hee Kang and Young Gon Kim and Takeshi F Andoh and Katherine L Gordon and Shin-ichi Suga and Marilda Mazzali and Jonathan Ashley Jefferson and Jeremy Hughes and William J. Bennett and George F. Schreiner and Richard J Johnson},
  journal={American journal of physiology. Renal physiology},
  volume={280 4},
Recent studies have demonstrated a role for microvascular and tubulointerstitial injury in some models of salt-sensitive hypertension. We utilized a model of post-cyclosporin A (CsA) nephropathy and hypertension to test the hypothesis that treatment with an angiogenic factor aimed at ameliorating the microvascular and renal injury would prevent the development of hypertension. CsA was administered with a low-salt diet for 45 days, resulting in a renal lesion characterized by afferent… CONTINUE READING


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A role for vascular endothelial growth factor (VEGF) in salt-sensitive hypertension induced by transient angiotensin II generation (Abstract)

  • G Schreiner, A Protter, E Clemens, K Gordon, RJ. Johnson
  • J Am Soc Nephrol 10: 355A,
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1 Excerpt

after exposure to catecholamines

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develops after short - term exposure to angiotensin II

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