Post-conditioning with lipopolysaccharide reduces the inflammatory infiltrate to the injured brain and spinal cord: a potential neuroprotective treatment.

@article{Davis2005PostconditioningWL,
  title={Post-conditioning with lipopolysaccharide reduces the inflammatory infiltrate to the injured brain and spinal cord: a potential neuroprotective treatment.},
  author={Andrew E M Davis and Sandra J. Campbell and Panop Wilainam and Daniel C. Anthony},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 10},
  pages={
          2441-50
        }
}
Systemic infection often accompanies or precedes acute brain injury, but it remains unclear how the systemic response contributes to outcome. To examine this problem we have microinjected recombinant interleukin-1beta (IL-1beta), a cytokine associated with acute brain injury, into the rat brain parenchyma and either preceded or followed this challenge with the intravenous injection of lipopolysaccharide (LPS), which mimics systemic inflammatory response syndrome. The microinjection of IL-1beta… CONTINUE READING
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