Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine

@article{Zimmer2015PostchemotherapyCI,
  title={Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine},
  author={Philipp Zimmer and Andreas Mierau and Wilhelm Bloch and Heiko Klaus Str{\"u}der and Thorben H{\"u}lsd{\"u}nker and Alexander Schenk and Leonie Fiebig and Freek T Baumann and Moritz Hahn and Nina Reinart and Michael Hallek and Thomas Elter},
  journal={Leukemia \& Lymphoma},
  year={2015},
  volume={56},
  pages={347 - 352}
}
Abstract To assess the effects of chemoimmunotherapy on post-chemotherapy cognitive impairments (PCCI) in patients with B-cell non-Hodgkin lymphoma (NHL), we used objective and subjective measures of cognitive functions in combination with serum parameters and neuroelectric recordings. Self-perceived status of cognition, fatigue and emotional functioning were reduced in patients (n = 30) compared to healthy controls (n = 10). Cognitive performance was impaired in patients with NHL compared to… 
Early manifestation of mild cognitive impairment in B-cell non-Hodgkin’s lymphoma patients receiving CHOP and rituximab-CHOP chemotherapy
TLDR
Patients receiving R-CHOP regimen were found to have more increased IL-6 and IL-1β with more cognitive decline and thyroid abnormality as comparison to CHOP receiving patients.
[Chemotherapy-related Cognitive Impairment in Patients with Hodgkin Lymphoma - Pathophysiology and Risk Factors].
TLDR
The most frequently observed changes in cognitive function in patients suffering from CRCI are summarized and the possible pathophysiological mechanisms behind these changes and the risk factors that can increase the likelihood of cognitive functional impairment after chemotherapy of malignant tumors are described.
Neurocognitive function of lymphoma patients after treatment with chemotherapy
TLDR
Protection of the brain by ‘cognitive or brain reserve’ as a possible explanation for the effects of chemotherapy on the cognitive function of lymphoma patients is hypothesized.
Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment
TLDR
Higher-risk patients experienced impairments in executive function and memory suggesting that disease biology contributes to CRCI independent of treatment, according to Sociodemographic-adjusted linear regression models.
Electrophysiological biomarkers of chemotherapy-related cognitive impairment in hematological malignancy patients
TLDR
Outcome measures provide initial support for contributions from both tumor biology and chemotherapy toxicity to functional changes in attentional control network activity and both cancer groups showed evidence for reduced information processing capacity while completing a simulation of naturalistic driving behavior.
Cognitive impairment and chemotherapy: a brief overview.
Influence of polychemotherapy on cognitive functions in patients with lymphoproliferative diseases: literature review and personal clinical observations
TLDR
Cognitive defects negatively influence patients’ quality of life, significantly reduce their physical and mental working ability, everyday activity, make execution of professional duties difficult, besides they can complicate nursing.
Post-chemotherapy cognitive impairment in hematological patients: current understanding of chemobrain in hematology
TLDR
This review has examined some commonly used drugs for the treatment of hematological malignancies which are known to have a deleterious action on cognitive functions and the interactions between genetic risk, amyloid accumulation, intrinsic brain networks, and chemotherapy.
What is known and unknown about chemotherapy‐related cognitive impairment in patients with haematological malignancies and areas of needed research
TLDR
It appears that a subset of chemotherapy‐treated haematological malignancy survivors experience CRCI, and future research should focus on expanding the literature reviewed here with larger studies appropriately powered to assess cognition via objective and subjective measures in a longitudinal fashion to tease apart the impact of disease and the various forms of cancer treatment.
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