Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity.

@article{Brusa2008PostapoptoticTA,
  title={Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity.},
  author={Davide Brusa and Stefano Garetto and Giovanna Chiorino and Maria Scatolini and Elisa Migliore and Giovanni Camussi and Lina Matera},
  journal={Vaccine},
  year={2008},
  volume={26 50},
  pages={6422-32}
}
Critical issues for cytotoxic lymphocyte (CTL) cross-priming are (a) the maturation state of dendritic cells (DC), (b) the source of the tumor-associated antigens (TAA) and (c) the context in which they are delivered to DCs. Drug-induced apoptosis has recently been implicated in CTL cross-priming. However, since drug-treatment produces in vivo more tumor cells than the DC default apoptotic clearance program can cope with, they are expected to proceed to secondary necrosis and change their… CONTINUE READING
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