Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65

@inproceedings{Kiernan2003PostactivationTO,
  title={Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65},
  author={Rosemary Kiernan and Vanessa Br{\`e}s and Raymond Wai-Man Ng and Marie-Pierre Coudart and Selma El Messaoudi and Claude Sardet and Dongbin Jin and St{\'e}phane Emiliani and Monsef Benkirane},
  year={2003}
}
NFB represents a family of eukaryotic transcription factors participating in the regulation of various cellular genes involved in the immediate early processes of immune, acute-phase, and inflammatory responses. Cellular localization and consequently the transcriptional activity of NFB is tightly regulated by its partner I B . Here, we show that the p65 subunit of NFB is acetylated by both p300 and PCAF on lysines 122 and 123. Both HDAC2 and HDAC3 interact with p65, although only HDAC3 was able… CONTINUE READING

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Transcriptional Activity Is Regulated by Acetylation 2766 by gest on N ovem er 18

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  • J. Biol. Chem. 10.1074/jbc.M209572200
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