Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?

@inproceedings{Aryal2017PostResectionEO,
  title={Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?},
  author={Bibek Aryal and Toshiaki Shimizu and Jun Kadono and Akira Furoi and Teruo Komokata and Iwao Kitazono and Chihaya Koriyama and Munekazu Yamakuchi and Teruto Hashiguchi and Yutaka Imoto},
  booktitle={Journal of Cancer},
  year={2017}
}
Purpose: Serotonin (5-hydroxytryptamine, 5-HT) is well known for its growth stimulatory effect on several types of carcinoma and tumor cells. Since a large portion of 5-HT is stored and transported by platelets, the aim of this study was to assess the influence of platelet-sequestered 5-HT on post-resection hepatocellular carcinoma (HCC) recurrence. Methods: This pilot study was conducted in a cohort of forty patients diagnosed with HCC undergoing partial hepatectomy. 5-HT levels in serum… CONTINUE READING

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