Post‐translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes

@inproceedings{Aukrust2017PosttranslationalMO,
  title={Post‐translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes},
  author={Ingvild Aukrust and Linn Andersen Rosenberg and Mia Madeleine Ankerud and Vibeke Bertelsen and Hanne Holl{\aa}s and Jaakko Saraste and Ann Kari Grindheim and Anni Vedeler},
  booktitle={FEBS open bio},
  year={2017}
}
Various post-translational modifications (PTMs) regulate the localisation and function of the multifunctional protein Annexin A2 (AnxA2). In addition to its various tasks as a cytoskeletal- and membrane-associated protein, AnxA2 can function as a trans-acting protein binding to cis-acting sequences of specific mRNAs. In the present study, we have examined the role of Ser25 phosphorylation in subcellular localisation of AnxA2 and its interaction with mRNP complexes. Subcellular fractionation and… CONTINUE READING