Post‐poliomyelitis syndrome

  title={Post‐poliomyelitis syndrome},
  author={Daria A. Trojan and Neil R. Cashman},
  journal={Muscle \& Nerve},
Post‐poliomyelitis syndrome (PPS) is a common neurological disorder that occurs in a large proportion of individuals who have recovered from paralytic poliomyelitis. The main clinical features are new weakness, muscular fatigability, general fatigue, and pain. The primary criteria necessary for the diagnosis of PPS are a history of paralytic poliomyelitis, partial or complete recovery of neurological function followed by a period of stability (usually several decades), persistent new muscle… 

[Post-polio syndrome].

Post-polio syndrome (PPS) is characterized by new muscular weakness, atrophy, general and muscular fatigue, decreased endurance, pain, and loss of function several years after acute polio. Between

Post-poliomyelitis syndrome: case report.

The case of PPS is reported in a patient, 40 years, that thirty-five years after had had paralytic poliomyelitis, developed new symptoms of fatigue, muscular atrophy, dyspnea, difficulties in deambulation and muscular and joint pain.

[Post-polio syndrome. Part I. The "legacy" of forgotten disease, challenges for professionals and polio survivors].

  • E. Matyja
  • Medicine
    Neurologia i neurochirurgia polska
  • 2012
It is established that polio has an additional, slowly progressive phase, called post-polio syndrome (PPS) that develops 30-40 years after the acute poliomyelitis in 25-80% of paralytic and about 40% of nonparalytic polio survivors.

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

No validated diagnostic, monitoring, or prognostic markers have been developed in PPS to date and the mainstay of therapy centers on symptomatic relief and individualized rehabilitation strategies such as energy conservation and muscle strengthening exercise regimes.

A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: Consideration of the pathology of post‐polio syndrome

The features in this case may have represented the pathology of long‐standing and/or fatal PPS itself, and not ALS, thus raising doubt as to the clinical diagnosis of amyotrophic lateral sclerosis (ALS) following PPS.

Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Electromyographic and muscle biopsy findings including evidence of ongoing denervation cannot reliably distinguish between patients with or without Postpolio syndrome.


This article seeks to question the concept of polio as a static disease, since it is a process difficult to diagnose and treat, as in both cases presented here.

Post-polio syndrome: clinical manifestations and cerebrospinal fluid markers

In the light of recent studies demonstrating a partial beneficial effect of intravenous immunoglobulin, this article will focus on cerebrospinal fluid biomarkers reflecting disease activity and pathogenic processes in PPS.

Aging and sequelae of poliomyelitis.

Mise au point Aging and sequelae of poliomyelitis

The therapeutic care of this late functional deterioration requires regular monitoring check-ups in order to implement preventive measures and appropriate treatment of the onset of an authentic PPS.



Post-Polio Syndrome: Pathophysiology and Clinical Management

The epidemiology, pathophysiology, characteristics, assessment, and rehabilitation care of the patient with post-polio syndrome are reviewed.

Pathophysiology and diagnosis of post-polio syndrome.

There is no specific diagnostic test for post-poliomyelitis syndrome, which continues to be a diagnosis of exclusion in an individual with symptoms and signs of the disorder.

Neurological manifestations of the post-polio syndrome.

A better understanding of PPS and PPMA will allow more effective management of these patients' problems and might also provide insight into other motor neuron and neuromuscular junction diseases.

Predictive factors for post-poliomyelitis syndrome.

Disability in poliomyelitis sequelae.

The results of the study of 59 patients with poliomyelitis using a number of instruments for disability assessment, including a 4- to 5-year follow-up show that the main impact of disability for most patients is in mobility-related activities.

Epidemiology of the post-polio syndrome.

It is demonstrated that poliomyelitis patients are not equally susceptible to post-polio syndrome within the interval of 30-40 years after the original illness.

Late denervation in patients with antecedent paralytic poliomyelitis.

It is concluded that the extensive reinnervation of denervated muscle that occurs in paralytic poliomyelitis may be followed by late denervation of the previously reinnervate muscle fibers.

Overwork weakness with evidence of muscle damage in a patient with residual paralysis from polio.

  • P. Peach
  • Medicine
    Archives of physical medicine and rehabilitation
  • 1990
This case represents an overuse syndrome in which muscle fibers were being damaged through overuse, and the possible role of serum CPK in the diagnosis of, and in monitoring clinical intervention in, some polio survivors who experience overwork weakness is suggested.

Late changes in the motor unit after acute poliomyelitis

There was a significant association between the percentage of recordings demonstrating blocking and both the chronological age and the number of years since the attack of polio.