Post‐herpetic neuralgia case study: optimizing pain control

@article{Baron2004PostherpeticNC,
  title={Post‐herpetic neuralgia case study: optimizing pain control},
  author={R. Baron},
  journal={European Journal of Neurology},
  year={2004},
  volume={11}
}
  • R. Baron
  • Published 2004
  • Medicine
  • European Journal of Neurology
Post‐herpetic neuralgia (PHN) is a chronic pain syndrome associated with the reactivation of a primary infection with varicella zoster virus (chicken pox), which leads to a chronic infection of the dorsal root ganglia. Under various clinical circumstances, including immunosuppressive diseases or treatments and certain cancers, reactivation of the infection can occur in adults as shingles. Other factors such as psychological distress and stressful life events also appear to play a role in the… Expand
A Review Of Postherpetic Neuralgia
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In treating the acute phase of herpes zoster, apart from keeping the patient comfortable, an attempt must be made to prevent the development of PHN, which is recurrent or persistent localized pain arising or persisting in areas affected by herpesZoster at least 3 months after healing of the skin lesion. Expand
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*Correspondence rtaylor@nemaresearch.com; robert.taylor.phd@gmail.com (Robert Taylor Jr.) Abstract Introduction: Postherpetic neuralgia (PHN) is associated with moderate to severe pain withExpand
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Prevention of shingles by varicella zoster virus vaccination
TLDR
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Seven zoster reactivations in an immune competent patient: how many is too many?
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A rare case of recalcitrant HZV infection, including 7 reactivations over 3 years, in an immune competent patient, who self-referred to the clinic, and thus bypassed other specialties. Expand
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TLDR
Early antiviral treatment with famciclovir has shown promise of reducing the duration of postherpetic neuralgia, the most common complication of herpes zoster. Expand
Afferent large fiber polyneuropathy predicts the development of postherpetic neuralgia
TLDR
A mild generalized impairment of afferent A&bgr;‐fiber function (A&b gr;‐polyneuropathy) seems to be an important co‐factor in the development of PHN and impairment of vibration sense, i.e., impairment of Afferent A &bgr:‐fibers, may be used as a predictor of PHn. Expand
Epidemiology and Impact on Quality of Life of Postherpetic Neuralgia and Painful Diabetic Neuropathy
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Both conditions are common complications of their underlying disorders and can profoundly diminish the quality of life of affected persons. Expand
Famciclovir for the Treatment of Acute Herpes Zoster: Effects on Acute Disease and Postherpetic Neuralgia: A Randomized, Double-Blind, Placebo-Controlled Trial
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Famciclovir, a new antiviral agent, was approved for marketing by the Food and Drug Administration in June 1994 for the management of acute herpes zoster and its effect on postherpetic neuralgia remains controversial. Expand
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.
TLDR
Gabapentin is effective in the treatment of pain and sleep interference associated with PHN and Mood and quality of life also improve with gabapentin therapy. Expand
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Topical agents, such as capsaicin, aspirin, and lidocaine, may soon become one of the mainstays of therapy for PHN. Expand
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Early antiviral treatment with famciclovir has shown promise of reducing the duration of postherpetic neuralgia, the most common complication of herpes zoster. Expand
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TLDR
Patients with PHN have been studied using quantitative testing of primary afferent function, skin biopsies, and controlled treatment trials to provide a preliminary glimpse of the pain-generating mechanisms in PHN. Expand
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Controlled-release oxycodone is an effective analgesic for the management of steady pain, paroxysmal spontaneous pain, and allodynia, which frequently characterize postherpetic neuralgia. Expand
Nortriptyline versus amitriptyline in postherpetic neuralgia
TLDR
It is concluded that this study provides a scientific basis for an analgesic action of NT in PHN because pain relief occurred without an antidepressant effect, and that although there were fewer side effects with NT, AT and NT appear to have a similar analgesicaction for most individuals. Expand
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