Possible use of urinary modified RNA metabolites in the measurement of RNA turnover in the human body.

@article{Sander1986PossibleUO,
  title={Possible use of urinary modified RNA metabolites in the measurement of RNA turnover in the human body.},
  author={Gernot Sander and Heinrich Topp and Josef Wieland and G Heller-Sch{\"o}ch and Gerhard Sch{\"o}ch},
  journal={Human nutrition. Clinical nutrition},
  year={1986},
  volume={40 2},
  pages={
          103-18
        }
}
Modified building blocks are found in rRNA, tRNA and mRNA. Apart from pseudouridine these are mostly base- or ribose-methylated nucleosides. If these compounds are neither recycled nor degraded, they should be quantitatively excreted. For pseudouridine (Weissman et al., 1962; Dugaiczyk & Eiler, 1966) and 7-methylguanine (Craddock, Mattocks & Magee, 1968), urinary excretion has been shown to be quantitative. Since the turnover rates of rRNA and tRNA, which contain most of the modified… CONTINUE READING

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