Possible use of CSF glycosphingolipids for the diagnosis and therapeutic monitoring of lysosomal storage diseases.

@article{Kaye1992PossibleUO,
  title={Possible use of CSF glycosphingolipids for the diagnosis and therapeutic monitoring of lysosomal storage diseases.},
  author={Edward M. Kaye and M. David Ullman and Edwin H. Kolodny and William Krivit and J C Rischert},
  journal={Neurology},
  year={1992},
  volume={42 12},
  pages={2290-4}
}
We used a high-performance liquid chromatography method to measure CSF gangliosides, neutral glycolipids, and sulfatides in patients with lysosomal storage disorders. These measurements could be done on less than 1 milliliter of CSF. In patients with GM1 gangliosidosis, GM1 ganglioside was increased, and in GM2 gangliosidosis patients, GM2 ganglioside was increased in CSF. Sulfatides were variably increased in CSF early in the course of the disease and appeared to be a means of monitoring… CONTINUE READING